Protein Details: Aquaporin-6

Protein ID

ICDB_Pro_1226

Protein Name

Aquaporin-6

Gene Name

Aqp6

Organism

Mus musculus (Mouse)

Length

293 amino acids

AlphaFoldDB

AF-Q8C4A0-F1-model_v4.pdb

Function

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration; tubular endocytosis and acid-base metabolism.

Sequence

MEPGLCSRAYLLVGGLWTAISKALFAEFLATGLYVFFGVGSVLPWPVALPSVLQIAITFNLATATAVQISWKTSGAHANPAVTLAYLVGSHISLPRAMAYIAAQLAGATAGAALLYGVTPGGIRETLGVNVVHNSTSTGQAVAVELVLTLQLVLCVFASMDGRQTLASPAAMIGTSVALGHLIGIYFTGCSMNPARSFGPAVIVGKFAVHWIFWVGPLTGAVLASLIYNFILFPDTKTVAQRLAILVGTTKVEKVVDLEPQKKESQTNSEDTECLTSPCEEAVRSFSFTLGLC

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1126/science.1112014

RefSeq

NP_780296.1